The Copa del Rey returns this week, and Atlético Madrid are preparing to play their fourth match in nine days away to Segunda B outfit Reus on Tuesday evening.
Simeone has named a much-changed squad for the trip to Catalonia, which could serve as an audition for potential replacements for the injured Tiago to prove their worth.
After the dramatic late win against Sporting Gijón at the Vicente Calderón, Atlético now face another newcomer at the Benito Villmarin.
The red and whites need the three points to keep the pressure on Real Madrid and Barcelona at the top of the table, after the Catalans ran out 4-0 winners in El Clásico on Saturday.
After the comparatively disappointing result against Astana on Tuesday, Atlético Madrid will look to return to winning ways against La Liga newcomers Sporting Gijon at the Vicente Calderón.
Kick-off at the Vicente Calderón on Sunday evening is set for 18:15 CET.
Atlético Madrid begin the league season with a visit from La Liga newcomers UD Las Palmas on Saturday afternoon.
Kick-off at the Vicente Calderón is set for 20:30.
Atlético’s pre-season performances have been a shining example of how to defend. Simeone’s men kept clean sheets in games against Numancia, Oviedo, Real Sociedad, Cádiz and Real Betis amongst others, and they will be looking to continue the trend in the season opener.